Cell Lines and Cell Cultures
Genscript Corporation CytoSinct CD34 Nanobeads hum
The CytoSinct CD34 Nanobeads human are used for in vitro enrichment CD34 cells from fresh or frozen peripheral blood mononuclear cells (PBMCs) leukapheresis products or single cell suspension based on the surface expression of human CD34
Genscript Corporation CHO-K1/EDNRA Stable Cell Line
In mammals the endothelin (ET) family comprises three endogenous isoforms ET-1 ET-2 and ET-3 These endothelium-derived peptides perform their functions via two endothelin receptors classified as EDNRA and EDNRB EDNRA receptors are mainly localized in the vascular smooth muscle cells where they are the predominant sub-type and mediate vasoconstriction and proliferation Selective EDNRA antagonists are effective in the treatment of heart failure essential hypertension pulmonary hypertension and atherosclerosis
Genscript Corporation CHO-K1/GCGR/G15 Stable Cell L
Recombinant CHO-K1 cells stably overexpress human glucagon receptor (GCGR) on the surface and contain high levels of G protein G s to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/FFA2/G15 Stable Cell L
FFA2 (GPR43) is a 330-amino acid G-protein coupled receptor that binds to fatty acid FFA2 is highly selective expressed in leukocytes which suggests a role in the recruitment of these cell populations toward sites of bacterial infection
Genscript Corporation CHO-K1/mouse CD155 Stable Cell
CD155 commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5) is a type I transmembrane single-span glycoprotein and belongs to the nectins and nectin-like (Necl) subfamily CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV) an etiologic agent of the central nervous system disease poliomyelitis The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells CD155 may assist in an efficient humoral immune response generated within the intestinal immune system It s been shown that CD155 can be recognized and bind by DNAM-1 and CD96 which promotes the adhension migration and NK-cell killing Thus inducing cell-mediated tumor-specific immunity
American Research Products Inc Anti CD198 CCR8 GS
Anti-Human CD198/CCR8 (GS-1811/JTX-1811) Research Grade
Genscript Corporation CHO-K1/CASR Stable Cell Line
CASR is a calcium-sensing receptor and plays an important role in regulating PTH secretion It is expressed in many different tissues such as parathyroid pancreatic islet and insulinoma cells breast gastrinoma cells pituitary keratinocytes and human colon epithelial cells CASR Inhibits PTH secretion and parathyroid cellular proliferation in parathyroid glands or cells and also inhibits proliferation of colonic crypt cells Besides it can stimulate PTHrP secretion in prostate cell line and stimulate calcitonin secretion from thyroidal C-cells
Genscript Corporation CHO-K1/CXCR4/G15 Stable Cell
CXCR4 is a receptor for the C-X-C chemokine SDF-1 (Stromal Cell-Derived Factor 1) It is involved in haematopoiesis and cardiac ventricular septum formation and plays an essential role in vascularization of the gastrointestinal tract cerebellar development and survival of hippocampal-neuron of central nerve system CXCR4 also acts as a primary receptor for some HIV-2 isolates and as a co-receptor with CD4 for HIV-1 X4 viruses
Genscript Corporation HVEM-Fc Human
Herpes Virus Entry Mediator (HVEM) is a transmembrane protein that is the receptor for TNFSF14 (also known as LIGHT) and is therefore referred to asTNFRSF14 HVEM is expressed broadly on immune cells such as T cells natural killer (NK) cells and monocytes The interaction of 3 molecules of LIGHT with three molecules of HVEM forms a hexameric complex that leads to the recruitment and retention of effector cells and activates NK cells to produce large amounts of IFN- and GM-CSF In addition to the canonical binding partner LIGHT HVEM can also bind to the inhibitory signaling protein B- and T- lymphocyte attenuator (BTLA) which suppresses immune responses Therefore the HVEM network plays an important role in regulating immunity and the behavior of lymphocytes
Genscript Corporation CD47 Fc Chimera Human
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3 Integrin-associated protein (IAP) and Protein MER6 CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain CD47 is a 40 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily and an integral membrane protein that consists of a 123 amino acid (aa) extracellular domain (ECD) with a single Ig-like domain five membrane-spanning regions with short intervening loops and a 34 aa C-terminal cytoplasmic tail CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity CD47 is the receptor for SIRPA binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells CD47 Interaction with SIRPG mediates cell-cell adhesion enhances superantigen-
Genscript Corporation CHO-K1/mouse PD-L1 Stable Cell
Recombinant CHO-K1 cells stably overexpress mouse programmed cell death 1 ligand 1 (PD-L1) on the surface The surface expression of PD-L1 is validated by FACS analysis
Genscript Corporation CD47 Human
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP ) CD-47 acts as a don t eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers
Genscript Corporation HVEM-Fc Human
Herpes Virus Entry Mediator (HVEM) is a transmembrane protein that is the receptor for TNFSF14 (also known as LIGHT) and is therefore referred to asTNFRSF14 HVEM is expressed broadly on immune cells such as T cells natural killer (NK) cells and monocytes The interaction of 3 molecules of LIGHT with three molecules of HVEM forms a hexameric complex that leads to the recruitment and retention of effector cells and activates NK cells to produce large amounts of IFN- and GM-CSF In addition to the canonical binding partner LIGHT HVEM can also bind to the inhibitory signaling protein B- and T- lymphocyte attenuator (BTLA) which suppresses immune responses Therefore the HVEM network plays an important role in regulating immunity and the behavior of lymphocytes
Genscript Corporation ICOS Fc Chimera Human
Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene CD278 or ICOS (Inducible T-cell COStimulator) is a CD28-superfamily costimulatory molecule that is expressed on activated T cells It is thought to be important for Th2 cells in particular The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family It forms homodimers and plays an important role in cell-cell signaling immune responses and regulation of cell proliferation
Genscript Corporation CHO-K1/G15 Stable Cell Line
Recombinant CHO-K1 cells stably overexpress human G protein subunit alpha 15 (G 15) in the cytoplasm This protein enables G protein-coupled receptor binding activity and acts upstream of or within with a positive effect on calcium-mediated signaling